Introduction: What they say
Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.”
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Shikonin, found in Zicao (also known as purple gromwell), suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4
From Research findings to Therapeutic opportunity:
This study suggests that Shikonin, by increasing the expression of its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (figs. 1 -3).
Taken together, this study suggests that pharmacological formulations encompassing “Shikonin or its analogues or Shikonin in combination with other anticancer drugs“ may be used to inhibit B-Cell and myeloid leukemias.
Details of the research details:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How Shikonin increases the expression of IRF4?
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Citation: Boominathan, L., Natural product-derived therapy for Human Leukemias: Shikonin, found in Zicao (also known as purple gromwell), suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 20/December/2016, 10.23 pm, Genome-2-Bio-Medicine Discovery Center.
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