Natural product-derived therapy for Human Leukemias: Shikonin, found in Zicao (also known as purple gromwell), suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 20/December/2016

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Introduction: What they say

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Shikonin, found in Zicao (also known as purple gromwell),  suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4


From Research findings to Therapeutic opportunity:

This study suggests that Shikonin, by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (figs. 1 -3).

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Taken together, this study suggests that pharmacological formulations encompassing       “Shikonin or its analogues or Shikonin in combination with other anticancer drugs may be used to inhibit B-Cell and myeloid leukemias.

purple-gromwell

Figure 1. Shikonin, found in Zicao (also known as purple gromwell), functions as an anti-cancer agent against human leukemias

Figure 2. Shikonin increases the expression of IRF4

shikonin-increases-the-expression-of-irf4

Figure 3 Mechanistic insight into how Shikonin increases the expression of IRF4 to prevent cancer progression


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Undisclosed mechanistic information: How Shikonin increases the expression of IRF4?

Amount: $ 100

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References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L.,  Natural product-derived therapy for Human Leukemias: Shikonin, found in Zicao (also known as purple gromwell), suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 20/December/2016, 10.23  pm,  Genome-2-Bio-Medicine Discovery Center.

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