Natural product-derived therapy for Human Leukemias: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 16/December/2016, 9.59 pm

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Introduction: What they say

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4


From Research findings to Therapeutic opportunity:

This study suggests that Thymoquinone, by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (figs. 1 and 2).

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thymoquinone-increases-irf4-expression

Figure 1. Mechanistic insight into how Thymoquinone increases the expression of IRF4

Taken together, this study suggests that pharmacological formulations encompassing       “Thymoquinone or its analogues or  Thymoquinone in combination with other anticancer drugs may be used to inhibit B-Cell and myeloid leukemias.

Thymoquinone, isolated from Monarda Fistulosa, inhibits aberrant lipid biosynthesis in cancer cells via down-regulation of ACLY

Figure 2. Monarda Fistulosa. Thymoquinone, also found in Monarda Fistulosa, increases the expression of IRF4


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Undisclosed mechanistic information: How Thymoquinone increases the expression of IRF4?

Amount: $ 100

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# Research cooperation


References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L.,  Natural product-derived therapy for Human Leukemias: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 16/December/2016, 9.59 pm,  Genome-2-Bio-Medicine Discovery Center.

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