From Research findings to Therapeutic opportunity:
The study presented here suggests that Cirsiliol, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decrease BMI1 translocation; (iii) increase tumor suppressor INK4a/p16 expression; and (iv) restore chemosensitivity in drug-resistant Human cancers (Fig 1.).
Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing “Cirsiliol or its analogues or Cirsiliol in combination with any of known anti-cancer drugs” (figs. 2) may be used to inhibit cancer progression.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed information: How Cirsilol increases the expression of CADM1, and INK4a/p16?
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Citation: Boominathan, L., Natural product-derived therapy for overcoming chemoresistance in Human cancers: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 14/December/2016, 9.43 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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