Natural product-derived therapy for overcoming chemoresistance in Human cancers: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 14/December/2016, 9.43 pm

Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: MiR-411 increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 14/December/2016, 9.28 pm
December 14, 2016
Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor protein Grainyhead transcription factor-3 (GRHL3), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 14/December/2016, 9.49 pm
December 14, 2016
Show all

From Research findings to Therapeutic opportunity: 

The study presented here suggests that Cirsiliol, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decrease BMI1 translocation; (iii) increase tumor suppressor INK4a/p16 expression; and (iv) restore chemosensitivity in drug-resistant Human cancers (Fig 1.).

price-5

[easy_payment currency=”USD”]

Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing “Cirsiliol or its analogues or Cirsiliol in combination with any of known anti-cancer drugs” (figs. 2) may be used to inhibit cancer progression.

achillea-fragrantissima

Figure 1 Cirsiliol, isolated from Achillea fragrantissima, increases the expression of CADM1, inhibits BMI-1 translocation, increases tumor suppressor INK4a/p16 expression and inhibits chemoresistance via up-regulation of its target gene

Cirsiliol க்கான பட முடிவு

Figure 2. Cirsiliol


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How Cirsilol increases the expression of CADM1, and INK4a/p16?

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $5

For purchase and payment details, you may reach us at info@genomediscovery.org


References

CitationBoominathan, L., Natural product-derived therapy for overcoming chemoresistance in Human cancers: Cirsilol (3′,4′,5-trihydroxy-6,7-dimethoxyflavone), a flavone isolated from Achillea fragrantissima, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 14/December/2016, 9.43 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.