Natural product-derived therapy for overcoming chemoresistance in Human cancers:Luteolin, a flavonoid found in Salvia tomentosa, Perilla, and thyme among others, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 13/December/2016, 10.08 pm

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From Research findings to Therapeutic opportunity: 

The study presented here suggests that Luteolin, by increasing the expression of its target genes, it may: (i) increase the expression of CADM1; (ii) decreases BMI1 translocation; (iii) increases tumor suppressor INK4a/p16 expression; and (iv) restores chemosensitivity in drug-resistant Human cancers (Fig 1.).

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Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing “Luteolin or its analogues or Luteolin in combination with any of known anti-cancer drugs” (figs. 2, 3) may be used to inhibit cancer progression.

Figure 1 Luteolin, found in Salivia tomoentosa, among others, as indicated below,, increases the expression of tumor suppressor p53, and inhibits the expansion and activity of tumor-initiating cells in metastatic breast cancer via up-regulation of its target gene

Figure 1 Luteolin, found in Salivia tomoentosa, among others, as indicated below, increases the expression of CADM1, inhibits BMI-1 translocation, increases tumor suppressor INK4a/p16 expression  and inhibits chemoresistance via up-regulation of its target gene

Perilla

Fig. 2. Perilla

The chemical structure of luteolin

Fig 3. Luteolin


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How Luteolin increases the expression of CADM1, and INK4a/p16?

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References

CitationBoominathan, L., Natural product-derived therapy for overcoming chemoresistance in Human cancers:Luteolin, a flavonoid found in  Salvia tomentosa, Perilla, and thyme among others, increases the expression of CADM1, decreases BMI1 translocation, increases tumor suppressor INK4a/p16 expression and restores chemosensitivity in drug-resistant Human cancers via down regulation of its target gene, 13/December/2016, 10.08 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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