Natural product Life-extension therapy: EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), found in Livistona Chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/December/2016, 5.57 pm

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What they say?

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Natural product Life-extension therapy: EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), found in Livistona Chinensis,   inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span[easy_payment currency=”USD”]

price-50


Research findings to Therapeutic opportunity: 

This study suggests a natural product-based life extension therapy. EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), by suppressing the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase), it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity.   

ehhm-promotes-longevity

Figure 1. EHHM, found in Livistona Chinensis, extends mammalian lifespan via down-regulation of p70S6 Kinase

Thus, pharmacological formulations encompassing EHHM or its analogues or EHHM plus any of the known longevity-promoting compound(s)” can be used to extend the lifespan of an individual.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How does EHHM promote mammalian life span?

# Research cooperation

Amount: $50#


References:

CitationBoominathan, L.,  Natural product Life-extension therapy: EHHM (E‑[6′-(5′-hydroxypentyl)tricosyl]-4-hydroxy-3-methoxycinnamate), found in Livistona Chinensis,   inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/December/2016, 5.59 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com

Courtesy: When you cite drop us a line at info@genomediscovery.org

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