Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1, 09/December/2016, 11.56 am

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 What they say: Introduction

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published in the 1 July  2014 issue of the journal  “EMBO” by Prof Sinclair, North BJ, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1. 


What is known? 

I have recently shown that  2,4,5-trihydroxybenzaldehyde (TDB)(1) increases the expression of ERBB2/Her2 and promotes dedifferentiation of cardiomyocytes; and (2) decreases age-associated  weight gain, augments energy metabolism, improves physical activity and insulin sensitivity, promotes healthy lipid profile, and improves eye function


From Research Findings to Therapeutic Opportunity

This study suggests a natural product-based life extension therapy. 2,4,5-trihydroxybenzaldehyde (TDB), by increasing the expression of its target gene, it may increase the expression of BuBR1.

price-100[easy_payment currency=”USD”]

Thereby, it may: (1) delay diseases of aging; (2) slow down aging; and (3) prolong median life span. Thus, pharmacological formulations encompassing “2,4,5-trihydroxybenzaldehyde (TDB) or TDB plus any of the known longevity promoting drug (s)” may be used to extend the lifespan of an individual. 

 Geum japonicum

Figure1. Geum japonicum flower. 2,4,5-trihydroxybenzaldehyde (TDB), isolated from Geum japonicum , extends mammalian life span via up regulation of BuBR1

Figure2. Polygonum cuspidatum. TDB, which is also found in Polygonum cuspidatum, aids in lifespan extension

tdb

Fig 3. TDB functions as a longevity promoter via up regulation of a number of longevity-promoting genes, including BuBR1

 

 

 

Details on the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $100#

Undisclosed mechanistic information: How 2,4,5-trihydroxybenzaldehyde (TDB) increases the expression of BubR1 and extends mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


Reference

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., Natural product-derived Lifespan extension therapy: 2,4,5-trihydroxybenzaldehyde (TDB), found in Geum japonicum and Polygonum cuspidatum (PC), also known as Japanese knotweed, increases life span via up-regulation of its target gene BubR1, 09/December/2016, 11.56 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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