From Significance of the study to Public health relevance:
Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant p53-overexpressing tumors; (4) cancer causes the highest economic loss compared to all the known causes of death worldwide; and (5) cancer causes the considerable economic loss worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and stall metastatic progression and relapse of mutant p53-overexpressing human cancers.
From therapeutic strategy to Research Findings:
This study suggests a therapeutic strategy for stalling the progression of p53-deficient/deleted or mutant-p53 expressing human metastatic cancers. By activating tumor suppressor p53’s unmutated or rarely mutated “homologous protein such as TAp73” in p53-deficient or mutant-p53 expressing human metastatic cancers, one can stall them.
MiR-329, by decreasing the expression of its target genes, it may increase the expression of tumor suppressor TAp73. Thereby, it may inhibit the migration and invasion of metastatic cancer cells expressing mutant-p53.
Given the ability of MiR-329 to induce the expression of TAp73 in p53-mutated human tumors, pharmacological formulations encompassing “MiR-329 or its activators or MiR-329 in combination with other anticancer drugs“ may be used to inhibit the progression of p53-mutated invasive metastatic tumors.
Together, this study suggests an MiRNA-based therapy for p53-mutated metastatic human tumors.[easy_payment currency=”USD”]
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How MiR-329 increases the expression of TAp73
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Citation: Boominathan, L., Therapeutic insights into “awakening the sleeping/cancer-protecting angel” in mutant p53-expressing human tumors: MiR-329 increases the expression of tumor suppressor p53 homologue TAp73 and induces regression of p53-mutated human tumors via down regulation of its target gene, 19/December/2016, 10.04 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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