Monthly Archives: January 2017

Life-extension therapy: SMAD7 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 31/January/2017, 11.42 pm

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Life-extension therapy: SMAD7 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 31/January/2017, 11.42 pm

Cardiac rejuvenation therapy: Activin A suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 31/January/2017, 11.30 pm

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: Activin A suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 31/January/2017, 11.30 pm

Natural product-based Lifespan extension therapy: Naringenin, found in Grapefruits, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 31/January/2015, 9.02 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.  From research … Continue reading

Posted in Ideas | Comments Off on Natural product-based Lifespan extension therapy: Naringenin, found in Grapefruits, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 31/January/2015, 9.02 pm

Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Olea Europea leaf extract decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 31/January/2017, 10.23 am

Introduction: What they say A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” … Continue reading

Posted in Ideas | Comments Off on Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Olea Europea leaf extract decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 31/January/2017, 10.23 am

Lipid product-derived therapy for Metastatic human tumors: C-6 Ceramide, a cell-permeable analog of Ceramides, decreases the expression of c-Src protein, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 31/January/2017, 9.45 am

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes … Continue reading

Posted in Ideas | Comments Off on Lipid product-derived therapy for Metastatic human tumors: C-6 Ceramide, a cell-permeable analog of Ceramides, decreases the expression of c-Src protein, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 31/January/2017, 9.45 am

Natural product-derived therapy for Metastatic human tumors: Gambogic acid (GA), found in Garcinia hanburyi, decreases the expression of c-Src protein, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 30/January/2017, 12.13 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Metastatic human tumors: Gambogic acid (GA), found in Garcinia hanburyi, decreases the expression of c-Src protein, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 30/January/2017, 12.13 pm

Cardiac rejuvenation therapy: Special AT‑rich sequence‑binding protein‑1 (SATB1) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/January/2017, 11.13 am

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: Special AT‑rich sequence‑binding protein‑1 (SATB1) suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 30/January/2017, 11.13 am

Small molecule-based PD-1 pathway blockade for Human cancer therapy: FK506-binding protein 3 (FKBP3) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 30/January/2017, 5.45 am

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer.” This study was published in … Continue reading

Posted in Ideas | Comments Off on Small molecule-based PD-1 pathway blockade for Human cancer therapy: FK506-binding protein 3 (FKBP3) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 30/January/2017, 5.45 am

Molecular therapy for tuberculosis: MiRNA-494-3p increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 30/January/2017, 5.30 am

Introduction: What they say:  A study from the Max Plank Institute for Infection Biology, Berlin, Germany shows that “CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis.” This study was published in the 10 February 2014 issue of the“Journal of … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for tuberculosis: MiRNA-494-3p increases the expression of MKP-1, inhibits TLR2 signalling, secretion of Chemokine CXCL5, and recruitment of polymorphonuclear leukocytes (PMNs), decreases destructive pulmonary inflammation, promotes M. tuberculosis clearance and inhibits pulmonary tuberculosis via up-regulation of its target gene, 30/January/2017, 5.30 am

Vitamin-based Life-extension therapy: Cholecalciferol inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 29/January/2017, 11.14 am

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Vitamin-based Life-extension therapy: Cholecalciferol inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 29/January/2017, 11.14 am

Natural product-derived therapy for Myocardial Infarction: Pterostilbene (PTB), a natural product found in Blueberries, and Pterocarpus marsupium (PM) Heart wood (Vijaysar) among others, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 29/January/2017, 5.25 am

What they say:  A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L Boominathan … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Myocardial Infarction: Pterostilbene (PTB), a natural product found in Blueberries, and Pterocarpus marsupium (PM) Heart wood (Vijaysar) among others, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 29/January/2017, 5.25 am

Cardiac rejuvenation therapy: Pterostilbene (PTB), derived from blueberries and Pterocarpus marsupium (PM) (Vijaysar), suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 29/January/2017, 4.48 am

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: Pterostilbene (PTB), derived from blueberries and Pterocarpus marsupium (PM) (Vijaysar), suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 29/January/2017, 4.48 am

Anti-telomerase cancer therapy: Selenium suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 29/January/2017, 3.21 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: Selenium suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 29/January/2017, 3.21 am

Natural produc-derived for brain repair and Lifespan extension: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 27/January/2017, 11.45 pm

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated … Continue reading

Posted in Ideas | Comments Off on Natural produc-derived for brain repair and Lifespan extension: Thymoquinone, the most abundant component in Black Cumin– Nigella sativa and in Monarda Fistulosa, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 27/January/2017, 11.45 pm

Natural product-derived therapy for Metastatic human tumors: α-Solanine, found in bittersweet nightshade, and tomato among others, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 27/January/2017, 11.28 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Metastatic human tumors: α-Solanine, found in bittersweet nightshade, and tomato among others, decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 27/January/2017, 11.28 pm

Natural produc-derived for brain repair and Lifespan extension: Matrine, one of the components of Sophora flavescens, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 26/January/2017, 8.55 am

What they say: Introduction:   A recent study from the Department of Biochemistry & Molecular Pharmacology, Smilow Research Center, Howard Hughes Medical Institute, NYU School of Medicine, 522 First Avenue, New York, NY 10016, USA shows that Running Triggers VGF-Mediated … Continue reading

Posted in Ideas | Comments Off on Natural produc-derived for brain repair and Lifespan extension: Matrine, one of the components of Sophora flavescens, increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 26/January/2017, 8.55 am

Natural product-derived therapy for enhancing anti-cancer immunity: 3, 6 Dihydroxyflavone decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 26/January/2017, 12.15 am

Introduction: What they say:  A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.” This study was published in the 1 … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for enhancing anti-cancer immunity: 3, 6 Dihydroxyflavone decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 26/January/2017, 12.15 am

Cardiac rejuvenation therapy: Twist-1 , a protein that is known to promote epithelial to mesenchymal transition, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 26/January/2017, 12.00 am

Introduction: What they say A recent study from the Stem Cell Aging Group, Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain shows that “Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence.” This study was published in the … Continue reading

Posted in Ideas | Comments Off on Cardiac rejuvenation therapy: Twist-1 , a protein that is known to promote epithelial to mesenchymal transition, suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 26/January/2017, 12.00 am

Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor Let-7, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 25/January/2016, 11.54 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may increase the expression of tumor suppressor MiRNA Let-7. Thereby, it may inhibit proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations … Continue reading

Comments Off on Anticancer therapy targeting the cancer stem cells: MiRNA-9600 increases the expression of tumor suppressor Let-7, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 25/January/2016, 11.54 pm

MiRNA therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Kaempferol, found in Allium cepa, Aloe vera, Coccinia grandis, Moringa oleifera, & Rosmarinus officinalis among others, promotes an insulin-sensitized state via up-regulation of its target gene, 25/January/2017, 11.45 pm

Introduction: What they say:  A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published in the 30 September  2011 issue of … Continue reading

Posted in Ideas | Comments Off on MiRNA therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Kaempferol, found in Allium cepa, Aloe vera, Coccinia grandis, Moringa oleifera, & Rosmarinus officinalis among others, promotes an insulin-sensitized state via up-regulation of its target gene, 25/January/2017, 11.45 pm