Natural product-derived therapy for Myocardial Infarction: Tyrosol, found in Olive oil and argan oil among others, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 16/January/2017, 11.59 pm
What they say: A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March 2013 issue of Nature by Prof Dimmler, Boon, and others. What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Myocardial Infarction: Tyrosol, found in Olive […]
Natural product-derived therapy for Human Leukemias: Manumycin A, an antibiotic that acts as an inhibitor of farnesyltransferase (FTase), suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 16/January/2016, 11.45 pm
Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: […]
Fish oil therapy for glucose homeostasis and TIIDM: Docosahexaenoic acid (DHA), found in fish oil and algae oil among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 16/January/2017, 11.21 pm
Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published in the 12 December 2016 issue of […]
Natural product-derived therapy for Metastatic human tumors: β-Asarone (1-propenyl-2,4,5-methoxybenzol), found in herb Acorus calamus Linn, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 16/January/2017, 10.50 pm
Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.” This study was published in the 5 January 2017 issue of the […]
Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Sox2, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 16/January/2016, 10.14 pm
Research findings to Therapeutic opportunity: The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may decrease the expression of the protein that is enriched in cancer stem cells, Sox2. [easy_payment currency=”USD”] Thereby, it may inhibit proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-9600 activators” may be used to inhibit […]
