Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Honokiol, isolated from Magnolia-grandiflora/dealbata/obovata/officinalis, decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 5/January/2016, 2.40 pm

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Introduction: What they say

A study from Faculty of Medicine, Friedrich-Schiller-University, Germany shows that “Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals.” This research paper was published in the 30 November 2016 issue of the journal “Nature” [One of the best research journals in General Science with an I.F of 38+] by Prof.Lenhard Rudolph, Stefan Tümpel, Simon Schwörer and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Honokiol, isolated from Magnolia-grandiflora/dealbata/obovata/officinalis, decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes


What is known?

Prof. Lenhard Rudolph’s research team has recently shown that deletion of HOXA9 in mice results in a) down regulation of inhibitors of muscle stem cells function, including Wnt, TGFß, JAK/STAT and senescence signalling; and b) improved muscle stem cells regeneration and function. Conversely, overexpression of HOXA9 has been shown to promote ageing-associated features in muscle stems cells.


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, a natural product-based regenerative therapy for improving muscle strength and repair in the elderly. Honokiol, by increasing the expression of its target gene, it may decrease the levels of HOXA9 (fig.1).

honokiol-pormotes-regeneration-of-muscle-stem-cells-by-suppressing-hoxa9-expression

Figure 1. Mechanistic insight into how Honokiol promotes muscle stem cell regeneration. Honokiol, found in Magnolia grandlfora and among others, promotes muscle stem cell repair and regeneration via down regulation of HOXA9

Thereby, it may: (1) down regulate inhibitors of muscle stem cells function; and (2) improve of muscle stem cells regeneration and function. Thus, pharmacological formulations encompassing Honokiol, or its analogues or Honokiol plus any of the known compounds that promote muscle regeneration” may be used to suppress muscle stem-cell ageing, age-associated physiological decline and improve health span.
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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

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Undisclosed mechanistic information: How Honokiol decreases the expression of HOXA9

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References:

Web: http://genomediscovery.org or http://newbioideas.com/

Citation: Boominathan, L., Natural product-derived regenerative therapy for improving muscle repair and strength in the elderly: Honokiol, isolated from Magnolia-grandiflora/dealbata/obovata/officinalis, decreases the expression of HOXA9, increases skeletal muscle regeneration and improves muscle stem cells function and repair via up regulation of its target genes, 5/January/2016, 2.40 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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