Research findings to Therapeutic opportunity:
The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may decrease the expression of the protein that is enriched in cancer stem cells, Lin-28.
Thereby, it may inhibit proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-9600 activators” may be used to inhibit cancer progression.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Undisclosed mechanistic information: How does MiRNA-9600 decrease the expression of Lin-28 ?
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Citation: Boominathan, L., Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Lin-28, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 15/January/2016, 10.41 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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