Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Lin-28, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 15/January/2016, 10.41 pm

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Research findings to Therapeutic opportunity:  

The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may decrease the expression of the protein that is enriched in cancer stem cells, Lin-28.

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Thereby, it may inhibit proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing MiRNA-9600 activators” may be used to inhibit cancer progression.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed mechanistic information: How does MiRNA-9600  decrease the expression of Lin-28 ?

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References

CitationBoominathan, L., Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Lin-28, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 15/January/2016, 10.41 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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