Life-extension therapy: Pioglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/January/2017, 1.41 pm
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January 3, 2017What they say?
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Life-extension therapy:
Pioglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span
Research findings to Therapeutic opportunity:
This study reveals, for the first time, the known anti-diabetic drug Pioglitazone‘s unknown function as a lifespan-promoter.
Pioglitazone, by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Fig 1. The antidiabetic drug Pioglitazone may function as a longevity promoter. Pioglitazone, by suppressing the expression of p70 S6 Kinase, it may extend the lifespan.
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Thus, pharmacological formulations encompassing “Pioglitazone either alone or or in combination with any of the known longevity-promoting compound(s)“ may be used to extend the lifespan of an individual (fig. 1).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed Information: How Pioglitazone decreases the expression of p70 S6 Kinase and promotes mammalian life span?
# Research cooperation
Amount: $100 #
References:
Citation: Boominathan, L., Life-extension therapy: Pioglitazone, an antidiabetic medication, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 3/January/2017, 1.40 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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