Life-extension therapy: SMAD7 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 31/January/2017, 11.42 pm

Cardiac rejuvenation therapy: Activin A suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy and heart failure via up regulation of its target gene, 31/January/2017, 11.30 pm
January 31, 2017
Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of metastasis suppressor gene TPM1 and inhibits invasion, migration and metastasis of tumor cells via down regulation of its target gene, 1/February/2017, 5. 41 pm
February 1, 2017
Show all

What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Life-extension therapy: SMAD7 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity: 

SMAD7, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

SMAD7 suppresses p70S6 kinase expression

Fig 1. SMAD7 activators may function as longevity promoters by suppressing the expression of p70 S6 Kinase

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing “SMAD7  activators either alone or in combination with any of the known longevity-promoting compound(s) may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How does  SMAD7  decrease the expression of p70 S6 Kinase and promote mammalian life span?

# Research cooperation

Amount: $50#

For purchase and payment information, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L.,   Life-extension therapy: SMAD7 inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 31/January/2017, 11.41 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.