Life-extension therapy: Withacnistin, found in Acnistus arborescens, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 18/January/2017, 11.53 pm

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January 18, 2017
Steroid therapy for brain repair and Lifespan extension: Testosterone increases VGF and BDNF expression, promotes Oligodendrocytes (OP) proliferation, triggers myelination on neurons, reverts neural damage, produces antidepressant like effects, and prolongs lifespan via up-regulation of its target gene, 19/January/2017, 6.25 am
January 19, 2017
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What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Life-extension therapy: Withacnistin, found in Acnistus arborescens, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity: 

Withacnistin, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

Withacnistin inhibits p70 S6 KInase expression

Fig 1. Natural product-derived Withacnistin may function as a longevity promoter by suppressing the expression of p70 S6 Kinase

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Thus, pharmacological formulations encompassing “Withacnistin either alone or in combination with any of the known longevity-promoting compound(s) may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed mechanistic Information: How does  Withacnistin  decrease the expression of p70 S6 Kinase and promote mammalian life span?

# Research cooperation

Amount: $50#

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References:

CitationBoominathan, L.,   Life-extension therapy: Withacnistin, found in Acnistus arborescens, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 18/January/2017, 11.53 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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