Molecular therapy for Myocardial Infarction: MiR-540 inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 7/January/2017, 11.10 pm

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What they say

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for Myocardial Infarction: MiR-540 inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS


From Significance of the study to Public Health relevance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from  123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.


From Research Findings to Therapeutic Opportunity

MiR-540, by decreasing the expression of its target genes, it may increase the expression of PNUTS and the cellular immortality gene TelomeraseThereby, it may: (1) inhibit DNA damage responses, (2) increase Telomerase expression; (3) inhibit telomere shortening; (4) augment insulin sensitivity; and (5) promote cardiomyocyte survival/regeneration (figure 1).

mir-540-increases-pnuts-expression-and-inhibits-cardiac-ageing

Figure 1. MiR-540 functions as a cardioprotective agent. Mechanistic insights into how MiR-540 induces the expression PNUTS and Telomerase to promote Cardiac regeneration and survival and insulin sensitivity

Thus, by treating myocardial patients with MiR-540 or its activators (figure 1), one may prevent ageing-associated (or, stress-associated) decline in cardiac function. 

price-100[easy_payment currency=”USD”]

Together, this study suggests that pharmacological formulations encompassing MiR-540   or its activators or MiR-540 plus any of the known drugs that improve myocardial function”  may be used to improve cardiac function after myocardial infarction.  


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How MiR-540 increases the expression of PNUTS and Telomerase

Amount: $100#

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web:http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L.,  Molecular therapy for Myocardial Infarction: MiR-540 inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 7/January/2017, 11.10 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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