Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Puerarin, isolated from Cucurbita texana, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 3/January/2017, 11.53 am

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What is known?

I have published earlier that Puerarin may suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and Telomerase and inhibit cancer progression. 


From Research findings to Therapeutic opportunity: 

The study presented here suggests that Puerarin, by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD); (ii) increase 5-FU accumulation in cancer cells; (iii) augment and restore chemosensitivity in drug-resistant Human cancers; (iv) promote anti-tumor effect; and (v) enhance the efficacy of anticancer drug treatment.

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Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing ” Puerarin or its analogue either alone or in combination with  5-FU, or any other anticancer drugs” may be used to inhibit cancer progression (Figs. 1-3).

Purarin-isolated-from-kudzu-pueraria-radix-puerariae

Figure 2. Radix puerariae (Kudzu)

puerarin-isolated-from-pueraria-radix-puerariae-kudzu-plant

Figure 1. Gegen functions as an anticancer agent. Puerarin, isolated from Gegen (Pueraria root), promotes Chemosensitivity via down-regulation of Dihydropyrimidine dehydrogenase (DPYD)

Puerarin

Figure 3. Puerarin

Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How Puerarin decreases the expression of Dihydropyrimidine dehydrogenase (DPYD)?

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References

CitationBoominathan, L., Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Puerarin, isolated from Cucurbita texana, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 3/January/2017, 11.53 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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