Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 11/January/2017, 8.48 pm

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From Research findings to Therapeutic opportunity: 

The study presented here suggests that Calycosin, by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD); (ii) increase 5-FU accumulation in cancer cells; (iii) augment and restore chemosensitivity in drug-resistant Human cancers; (iv) promote anti-tumor effect; and (v) enhance the efficacy of anticancer drug treatment.

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Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing “Calycosin or its analogue either alone or in combination with  5-FU, or any other anticancer drugs” may be used to inhibit cancer progression (Figs. 1-3).

Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How Calycosin decreases the expression of Dihydropyrimidine dehydrogenase (DPYD)?

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References

CitationBoominathan, L., Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 11/January/2017, 8.48 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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