Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Guttiferone K (GUTK), found in Garcinia cambogia, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 13/January/2017, 10.31 pm

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From Research findings to Therapeutic opportunity: 

The study presented here suggests that Guttiferone K (GUTK), by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD); (ii) increase 5-FU accumulation in cancer cells; (iii) augment and restore chemosensitivity in drug-resistant Human cancers; (iv) promote anti-tumor effect; and (v) enhance the efficacy of anticancer drug treatment.

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Thereby, it may inhibit proliferation, chemoresistance and apoptosis of cancer cells. Thus, pharmacological formulations encompassing “Guttiferone K (GUTK) or its analogue either alone or in combination with  5-FU, or any other anticancer drugs” may be used to inhibit cancer progression (Figs. 1-3).

Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How Guttiferone K (GUTK) decreases the expression of Dihydropyrimidine dehydrogenase (DPYD)?

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References

CitationBoominathan, L., Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Guttiferone K (GUTK), found in Garcinia cambogia, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 13/January/2017, 10.30 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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