Natural product-derived Immune enhancement therapy: Areca Nut extract/Arecoline increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 12/January/2017, 10.07 pm

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Introduction: What they say:  

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973] by Drs. Zusen Fan, Xia and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Immune enhancement therapy: Areca Nut extract/Arecoline increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene


From Research Findings to Therapeutic Opportunity:

This study suggests, for the first time, Arecolineby decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. 

Areca nut palm

Figure1. Areca nut palm. Areca nut extract or Arecoline increases the expression of Sox2 to promote innate immunity against bacterial infection.

Arecoline க்கான பட முடிவு

Figure 2. Arecoline

price-100

Together, pharmacological formulations encompassing Arecoline or its analogues or Arecoline in combination with other drugs” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1-2). 


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Arecoline(1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?

Amount: $100

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L., Natural product-derived Immune enhancement therapy:  Areca Nut extract/Arecoline increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 12/January/2017, 10.07 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com/

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