Natural product-derived Immune enhancement therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 20/January/2017, 10.27 pm

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Introduction: What they say:  

A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973] by Drs. Zusen Fan, Xia and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived Immune enhancement therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. giganteanincreases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene


From Research Findings to Therapeutic Opportunity:

This study suggests, for the first time, Methyl 3,5-dicaffeoyl quinate (MDQ)by decreasing the expression of its target gene, it may : (1) increase the expression of Sox2; (2) increase the ability of Sox2 to recognize bacterial DNA in cytoplasm; and (3) promote innate immunity against bacterial infection. 

price-100

Together, pharmacological formulations encompassing Methyl 3,5-dicaffeoyl quinate (MDQ) or its analogues or Methyl 3,5-dicaffeoyl quinate (MDQ) in combination with other drugs” may be used to (1) enhance innate immunity against bacterial infection; and (2) promote bacterial resistance (figs. 1-4).

Castor-aralia (kalopanax-pictus)

Figure 1. Castor-aralia (kalopanax-pictus). Methyl 3,5-dicaffeoyl quinate (MDQ), found in Castor-aralia (kalopanax-pictus) among others, as indicated below,. increase the expression of Sox2 and promote innate immunity against bacterial infection.

Salicornia herbacea L

Figure 2. Salicornia herbacea L

 


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan Ph.D.

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Undisclosed mechanistic information: How Methyl 3,5-dicaffeoyl quinate (MDQ): (1) enhances innate immunity against bacterial infection; and (2) promotes bacterial resistance?

Amount: $100

# Research cooperation

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References:

CitationBoominathan, L., Natural product-derived Immune enhancement therapy: Methyl 3,5-dicaffeoyl quinate (MDQ), a flavonoid glucoside found in Castor-aralia (kalopanax-pictus), Salicornia herbacea L., Aster oharai and Solidago virga-aurea var. gigantean, increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 20/January/2017, 10.27 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com/

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