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Introduction: What they say

A study from the Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA shows that “The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.” This study was published in the 1 December 2016 issue of the journal “Cell” [the number 1 journal in General Biology with an I.F of 28.710] by Prof. Guan KL, Moroishi T, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived  therapy for enhancing anti-cancer immunity:  Withaferin A, one of the main components of Acnistus arborescens, and Ashwagantha among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene


From Significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a way to prevent an individual from being susceptible to cancer by strengthening his/her own immune system; (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and prevent metastatic progression and relapse of cancers.


What we infer from what they say:

Prof. Guan’s research team has recently shown that deletion of Lats1/2 in tumor cells: (1) augments  cytotoxic T cells activity; (2) enhances antibody production by B-cells; (3) enhances anti-tumor immunity by stimulating TLRs-MYDD/TRIF-IFN-I pathway; (4) enhances YAP (Yes-associated protein) activity; and (5) augments tumor vaccine efficacy, suggesting that inhibition of LATS1/2 expression in cancer cells will augment immune system’s ability to prevent tumor growth.


From research findings to therapeutic opportunity : 

This study suggests a natural product-derived therapy for augmenting anti-cancer immunity. Withaferinis known to function as an anticancer agent. However, the detailed mechanism of action is yet to emerge.

price-300[easy_payment currency=”USD”]

Withaferin Aby decreasing the expression of its target genes, it may decrease the expression of LATS1/2. Thereby, it may: (i) enhance Cytotoxic T-cell activity and antibody production by B-cells; (ii) enhance anti-tumor immunity via Interferon-I pathway (TLRs-MYDD/TRIF); (iii) increase the expression of transcriptional coactivator YAP, possibly, its target gene p53 homologue TAp73; (iv)  increase tumor vaccine efficacy; and (v) promote tumor regression (fig.1).

withaferin-a-inhibits-lats1-2-expression-to-promote-anticancer-immmunity

Figure 1. Mechanistic insights into how Withaferin A functions as an anti-cancer agent. Withferin A suppresses the expression of Lats1/2 and activates Interferon-I pathway to promote tumor regression.

Thus, pharmacological formulations encompassing Withaferin A  or its analogues or Withaferin A  in combination with other known anticancer drugs(figs. 2-5)) may be used to strengthen cancer patients immune system to prevent tumor growth and cancer progression.


Details of the Research findings:  

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Amount: $300#

Undisclosed mechanistic information: How does Withferin A decrease the expression of LATS1/2 to inhibit tumor growth?

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References: 

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Natural product-derived  therapy for enhancing anti-cancer immunity:  Withaferin A, one of the main components of Acnistus arborescens, and Ashwagantha among others, decreases the level of LATS1/2 (large tumor suppressor 1 and 2), increases immunogenicity of tumors, enhances anti-tumor immune responses, and inhibits tumor growth via down regulation of its target gene, 5/January/2017, 11.43 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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