Natural product-derived therapy for H. pylori–induced Gastric cancer: Amla extract inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation, inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 4/January/2017, 5.48 am

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From Research findings to Therapeutic opportunity: 

The study presented here suggests that Amla extract, by increasing the expression of its target genes, it may: (i) inhibit WNT-SOX9 oncogenic pathway; (ii) decrease oncogenic β-catenin protein levels; (iii) decrease H. pylori-induced gastric cancer cell proliferation; (iv) inhibit acquisition of tumor-initiating stem-cell properties; and (v) decrease chemoresistance.

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Thereby, it may inhibit proliferation of H.Pylori-induced gastric cancer cells. Thus, pharmacological formulations encompassing Amla extract or an active compound isolated from it or Amla extract in combination with  any other anticancer drugs” may be used to inhibit cancer progression (Fig. 1).

Figure 1. Amla extract functions as an anticancer agent in H.Pylori-induced gastric cancer. Amla extract promotes Chemosensitivity via inhibition of WNT-SOX9 oncogenic pathway

Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How Amla extract inhibits the WNT-SOX9 oncogenic pathway?

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References

CitationBoominathan, L., Natural product-derived therapy for H. pylori –induced Gastric cancer: Amla extract inhibits WNT-SOX9 pathway, decreases oncogenic β-catenin levels, suppresses H. pylori-induced gastric cancer proliferation,  inhibits acquisition of tumor-initiating stem-cell properties and decreases chemoresistance via up regulation of its target gene, 4/January/2017, 5.48 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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