Natural product-derived therapy for Human Leukemias: Neo-tanshinlactone D-ring, isolated from Salvia miltiorrhiza, one of the main components of feverfew, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 6/January/2016, 10.48 pm

Anti-telomerase cancer therapy: MiR-486 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and inhibits cancer progression via down-regulation of it target gene, 6/January/2017, 10.20 pm
January 6, 2017
Molecular therapy for Myocardial Infarction: Myricitrin, found in herb Bayberry/Myrica cerifera, inhibits DNA damage responses, increases telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 6/January/2017, 11.10 pm
January 6, 2017
Show all

Introduction: What they say

Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” 


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Neo-tanshinlactone D-ring, isolated from Salvia miltiorrhiza, one of the main components of feverfew, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4


From Research findings to Therapeutic opportunity:

This study suggests that Neo-tanshinlactone D-ring, by increasing the expression of  its target gene, it may increase the expression of a number of tumor suppressor genes, including IRF4. Thereby, it could inhibit the progression of B-Cell and myeloid leukemias (fig. 1).

price-100

[easy_payment currency=”USD”]

Taken together, this study suggests that pharmacological formulations encompassing       Neotanshinlactone D-ring or its analogues or Neo-tanshinlactone D-ring in combination with other anticancer drugs may be used to inhibit B-Cell and myeloid leukemias.

neo-tanshinialactone-dring-increases-irf4-activation

Figure 1 Mechanistic insight into how Neo-tanshinlactone D-ring increases the expression of IRF4 to prevent cancer progression


Details of the research details

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Neo-tanshinlactone D-ring increases the expression of IRF4?

Amount: $ 100

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or newbioideas.com

CitationBoominathan, L., Natural product-derived therapy for Human Leukemias: Neo-tanshinlactone D-ring, isolated from Salvia miltiorrhiza, one of the main components of feverfew, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 6/January/2016, 10.48 pm,  Genome-2-Bio-Medicine Discovery Center.

Courtesy: When you cite drop us a line at admin@genomediscovery.org

Comments are closed.