Natural product-derived therapy for Metastatic human tumors: Boehmenan, a lignan from the Chinese medicinal plant Clematis armandi, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 13/January/2017, 11.27 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.” This study was published in the 5 January 2017 issue of the […]

Natural product therapy for glucose homeostasis and TIIDM: Sulforaphane, found in Broccoli sprouts and Cauliflower, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensisitity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 13/January/2017, 11.01 pm

Introduction: What they say A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative islet cell types.” This research paper was published in the 12 December 2016 issue of […]

Natural product-derived combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: Guttiferone K (GUTK), found in Garcinia cambogia, decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 13/January/2017, 10.31 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that Guttiferone K (GUTK), by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD); (ii) increase 5-FU accumulation in cancer cells; (iii) augment and restore chemosensitivity in drug-resistant Human cancers; (iv) promote anti-tumor effect; and (v) enhance the efficacy of anticancer […]

Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor Interleukin-1β (IL-1β), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 13/January/2016, 10.26 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may increase the expression of Interleukin-1β (IL-1β). [easy_payment currency=”USD”] Thereby, it may inhibit proliferation, and promote apoptosis of cancer cells. Thus, pharmacological formulations encompassing “MiRNA-9600 activators” may be used to inhibit cancer progression. Details of the research findings:  Idea […]

Natural product-derived Life-extension therapy: Sauchinone, an antioxidant lignan found in Saururus chinensis, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/January/2017, 10.19 am

What they say?  A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others. What we […]

Immune enhancement therapy: Estradiol (E2) increases SOX2 expression and promotes innate immunity against bacterial infection via down-regulation of its target gene, 13/January/2017, 10.10 pm

Introduction: What they say:   A recent study from the Institute of Biophysics, Chinese Academy of Sciences, Beijing, China shows that “Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection.” This study was published in the 2 March 2015 issue of the Journal “Nature Immunology” [the number one journal in immunological research with an impact factor of  24.973] by […]