Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: β-Caryophyllene oxide (CPO), found in oregano, cinnamon, clove, and black pepper among others, increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/January/2017, 11.11 pm

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From Significance of the study to Public health relevance

Given that: (1) Cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant p53-overexpressing tumors; (4) cancer causes the highest economic loss compared to all the known causes of death worldwide; and (5) cancer causes the considerable economic loss worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and stall metastatic progression and relapse of mutant p53-overexpressing human cancers.


From therapeutic strategy to Research Findings:

(i) Therapeutic strategy: 

This study suggests a therapeutic strategy for stalling the progression of p53-deficient/deleted or mutant-p53 expressing metastatic cancers. By activating tumor suppressor p53’s unmutated “homologous protein such as TAp73/p63” in p53-deficient or mutant-p53 expressing metastatic cancer cells, one can stall their progression.

(ii) Research findings:  

A number of studies suggests that β-Caryophyllene oxide (CPO) functions as an anticancer agent. However, the mechanism of action is far from clear. This study suggests that β-Caryophyllene oxide (CPO), by decreasing the expression of its target gene, it may not only increase the expression of tumor suppressors genes, such as TAp73, TAp63, PTEN, INK4a etc., but also increase a number of metastatic suppressor genes, such as TPM1, TIMP3, BTG2, PDCD4, SPRY1/2, CCM1/KRIT1, E-Cadherin, BRMS1, MTSS1 etc. Thereby, it may inhibit the migration and invasion of metastatic cancer cells expressing mutant-p53 (figure1).

β-Caryophyllene oxide (CPO) induces p73 and p63 and promote tumor regression

Figure 1. Mechanistic insights into how β-Caryophyllene oxide (CPO) functions as an anticancer/antimetastatic agent.  β-Caryophyllene oxide (CPO),  by activating tumor suppressor genes, such as TAp73, TAp63, PTEN, PDCD4, BTG2, E-Cadherin etc., and metastatic suppressor genes, such as TPM1, TIMP3, SPRY1/2 etc., in  metastatic tumors, it may inhibit the progression of mutant-p53 expressing human cancers.


Therapeutic opportunity:

Given the ability of β-Caryophyllene oxide (CPO) to induce the expression of TAp73, TAp63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2, CCM1/KRIT1, long ncRNA Gas5 in p53-mutated human tumors, pharmacological formulations encompassing β-Caryophyllene oxide (CPO) or its analogues or β-Caryophyllene oxide (CPO) plus any of the known anticancer agents” may be used to inhibit the progression of p53-mutated invasive metastatic tumors.

price-100

Together, this study provides, for the first time, a detailed mechanistic insight into how the β-Caryophyllene oxide (CPO)  may function as an anticancer/antimetastatic agent.

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Details of the research findings

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $100#

Undisclosed mechanistic information: How  β-Caryophyllene oxide (CPO) increases the expression of tumor suppressor genes (TAp73, TAp63, and PTEN); and metastatic suppressor genes (TPM1, TIMP3, BTG2, PDCD4, SPRY1/2, CCM1/KRIT1, RECK) in mutant p53 expressing cancer cells?

For purchase and payment details, you may reach us at admin@genomediscovery.org

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References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Therapeutic insights into “awakening the sleeping/cancer-protecting angels” in mutant p53-expressing human tumors: β-Caryophyllene oxide (CPO), found in oregano, cinnamon, clove, and black pepper among others,  increases the expression of tumor suppressor p53 homologue TA-p73/p63, PTEN, TPM1, TIMP3, BTG2, PDCD4, SPRY1/2 and CCM1/KRIT1 and induces regression of p53-mutated human tumors via down regulation of its target gene, 22/January/2017, 11.11 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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