Monthly Archives: February 2017

Natural product-derived therapy for EVI-1-Overexpressing Acute Myeloid Leukemia: Z-ajoene, derived from Garlic, decreases the expression of MECOM/EVI-1 and its down target genes, including CKMT-1, alters Arginine-creatine metabolism, inhibits mitochondrial respiration, depletes ATP levels, and promotes regression of EVI-1-overexpressing AML via up regulation of its target gene, 28/February/2017, 3. 00 pm

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med ideas posted today (28/February/2017) will be available to the use of Scientists/Professors/Teachers/Physicians/Researchers for free. So, there will be no … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for EVI-1-Overexpressing Acute Myeloid Leukemia: Z-ajoene, derived from Garlic, decreases the expression of MECOM/EVI-1 and its down target genes, including CKMT-1, alters Arginine-creatine metabolism, inhibits mitochondrial respiration, depletes ATP levels, and promotes regression of EVI-1-overexpressing AML via up regulation of its target gene, 28/February/2017, 3. 00 pm

Natural product-derived therapy for Acute Myeloid Leukemia: Eriocitrin, one of the components in Lemons, decreases the expression of BCLAF1, promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 28/February/2017, 10.47 am

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med ideas posted today (28/February/2017) will be available to the use of Scientists/Professors/Teachers/Physicians/Researchers for free. So, there will be no … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Acute Myeloid Leukemia: Eriocitrin, one of the components in Lemons, decreases the expression of BCLAF1, promotes differentiation of acute myeloid leukemic cells, restores treatment responsiveness, increases therapeutic index of anticancer drugs, and promotes regression of AML via up-regulation of its target gene, 28/February/2017, 10.47 am

Small molecule-based therapy for Metastatic cancers: Rapamycin (also known as Sirolimus), an immuno suppressor and a longevity promoting drug, increases the expression of tumor suppressor KRIT1/CCM1, sensitize cancer cells to apoptosis, and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 9.42 am

National Science day special ********* We wish everyone a very happy national science day. On this special occasion, we are happy to announce that Bio-Med ideas posted today (28/February/2017) will be available to the use of Scientists/Professors/Teachers/Physicians/Researchers for free. So, there will be no … Continue reading

Posted in Ideas | Comments Off on Small molecule-based therapy for Metastatic cancers: Rapamycin (also known as Sirolimus), an immuno suppressor and a longevity promoting drug, increases the expression of tumor suppressor KRIT1/CCM1, sensitize cancer cells to apoptosis, and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 9.42 am

Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of PDCD4, sensitize cancer cells to apoptosis, and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 8.47 am

National Science day special ********* We wish everyone a very happy National Science day. On this special occasion, we are happy to announce that Bio-Med ideas posted today (28/February/2017) will be available to the use of Scientists/Professors/Teachers/Physicians/Researchers for free. So, there will be no … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of PDCD4, sensitize cancer cells to apoptosis, and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 8.47 am

Natural product-derived therapy for Metastatic cancers: Naringenin, a flavonoid found in grapefruit, oranges, and tomatoes (skin) among others, decreases the expression of PMP22 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 6.46 am

National Science day special ********* We wish every one a very happy National Science day. On this special occasion, we are happy to announce that ideas posted today (28/February/2017) will be available to the use of Scientists/Professors/Teachers/Physicians/Researchers for free. So, there will be no … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Metastatic cancers: Naringenin, a flavonoid found in grapefruit, oranges, and tomatoes (skin) among others, decreases the expression of PMP22 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 28/February/2017, 6.46 am

Small molecule-based PD-1 pathway blockade for Human cancer therapy: Metformin, the widely used drug in the treatment of TIIDM, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 27/February/2017, 9.27 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to … Continue reading

Posted in Ideas | Comments Off on Small molecule-based PD-1 pathway blockade for Human cancer therapy: Metformin, the widely used drug in the treatment of TIIDM, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 27/February/2017, 9.27 pm

Natural product-based therapy for Metabolic diseases: Fla-CN, a flavonoid derivative of tiliroside, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 27/February/2017, 6.32 pm

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published in the June 8, 2011 Nature [One of the best … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Metabolic diseases: Fla-CN, a flavonoid derivative of tiliroside, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 27/February/2017, 6.32 pm

Vitamin-based therapy for Metastatic cancers: Ascorbate (Vitamin-C), found abundantly in Kakadu plum/murunga, and camucamu among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/February/2017, 8.36 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be … Continue reading

Posted in Ideas | Comments Off on Vitamin-based therapy for Metastatic cancers: Ascorbate (Vitamin-C), found abundantly in Kakadu plum/murunga, and camucamu among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/February/2017, 8.36 am

Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am

Natural product-derived therapy for Human Leukemias: Gentian Violet, isolated from Gentianopsis Crinita, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 27/February/2017, 5.38 am

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.”  What we say: On the foundation of this … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Human Leukemias: Gentian Violet, isolated from Gentianopsis Crinita, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 27/February/2017, 5.38 am

Natural product-derived therapy for glucose homeostasis and TIIDM: Oliganol, isolated from fruit Lynchee, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 26/February/2017, 11.47 pm

Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in the September 14, 2014 issue of the Journal “Journal of Experimental Medicine (JEM)” that: … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for glucose homeostasis and TIIDM: Oliganol, isolated from fruit Lynchee, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 26/February/2017, 11.47 pm

Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 26/February/2017, 11.14 am

Research findings to Therapeutic opportunity:  A number of studies suggest that Hyperoside functions as an anticancer agent. However, the mechanism of action is far from clear. This study suggests that Hyperoside, by decreasing the expression of its target genes, it may … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 26/February/2017, 11.14 am

Natural product-derived therapy for glucose homeostasis and TIIDM: Lycium barbarum polysaccharide (LBP), isolated from Goji Berry (Wolfberry), increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 26/February/2017, 12.37 am

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for glucose homeostasis and TIIDM: Lycium barbarum polysaccharide (LBP), isolated from Goji Berry (Wolfberry), increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 26/February/2017, 12.37 am

Natural product-derived therapy for Diabetic Kidney disease: Thymoquinone, one of the major constituents of Nigella Sativa, decrease VEGF-B expression, inhibit lipid accumulation in Podocytes, promote insulin signalling in Podocytes, induce insulin sensitivity, ameliorate renal dysfunction and alleviate diabetic kidney disease via down regulation of its target gene, 26/February/2017, 12.07 am

Introduction: What they say A study from the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden shows that “Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.” This research … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Diabetic Kidney disease: Thymoquinone, one of the major constituents of Nigella Sativa, decrease VEGF-B expression, inhibit lipid accumulation in Podocytes, promote insulin signalling in Podocytes, induce insulin sensitivity, ameliorate renal dysfunction and alleviate diabetic kidney disease via down regulation of its target gene, 26/February/2017, 12.07 am

Natural product-derived therapy for glucose homeostasis and TIIDM: Celastrol, isolated from herb Thunder God Vine, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 25/February/2017, 11.17 pm

Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in the September 14, 2014 issue of the Journal “Journal of Experimental Medicine (JEM)” that: … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for glucose homeostasis and TIIDM: Celastrol, isolated from herb Thunder God Vine, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 25/February/2017, 11.17 pm

Natural product-derived therapy for Human Leukemias: Lutein, one of the main components of Marygold, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 25/February/2017, 10.51 pm

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.”  What we say: On the foundation of this … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Human Leukemias: Lutein, one of the main components of Marygold, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 25/February/2017, 10.51 pm

Anti-telomerase cancer therapy: MAG13 (Membrane Associated Guanylate Kinase Inverted 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 25/February/2017, 10.34 pm

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: MAG13 (Membrane Associated Guanylate Kinase Inverted 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 25/February/2017, 10.34 pm

Natural product/vitamin-based Combination therapy for PTEN-deficient cancer: Combination of Schisandrin B, Cholecalciferol and ATRA decreases the expression of CHD1, increases the expression of a number of tumor suppressor genes, inhibits pro-survival TNF-NF-kB gene network, and suppresses tumorigenesis of PTEN-deficient cancer, 24/February/2017, 11.43 pm

Introduction: What they say: A study from the Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA shows that “Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.” This study was published … Continue reading

Posted in Ideas | Comments Off on Natural product/vitamin-based Combination therapy for PTEN-deficient cancer: Combination of Schisandrin B, Cholecalciferol and ATRA decreases the expression of CHD1, increases the expression of a number of tumor suppressor genes, inhibits pro-survival TNF-NF-kB gene network, and suppresses tumorigenesis of PTEN-deficient cancer, 24/February/2017, 11.43 pm

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Bergapten, isolated from Bergamot, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/February/2017, 11.27 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows that “Deubiquitination and Stabilization of PD-L1 by CSN5.” This study … Continue reading

Posted in Ideas | Comments Off on Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Bergapten, isolated from Bergamot, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/February/2017, 11.27 pm

Combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: 15-deoxy-delta(12,14)-prostaglandin J2 (PGJ2) decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 24/January/2017, 11.01 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that 15-deoxy-delta(12,14)-prostaglandin J2 (PGJ2), by increasing the expression of its target genes, it may: (i) decrease the expression of Dihydropyrimidine dehydrogenase (DPYD); (ii) increase 5-FU accumulation in cancer cells; (iii) augment and restore chemosensitivity … Continue reading

Posted in Ideas | Comments Off on Combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: 15-deoxy-delta(12,14)-prostaglandin J2 (PGJ2) decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 24/January/2017, 11.01 pm