Monthly Archives: February 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Morin (3,5,7,2′,4′-pentahydroxyflavone), found in Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and leaves of Psidium guajava (common guava), increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 23/February/2017, 11.49 pm

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for glucose homeostasis and TIIDM: Morin (3,5,7,2′,4′-pentahydroxyflavone), found in Maclura pomifera (Osage orange), Maclura tinctoria (old fustic) and leaves of Psidium guajava (common guava), increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 23/February/2017, 11.49 pm

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Valproic acid and Deoxycholic acid, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 23/February/2017, 10.38 pm

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies.” This study was published in the 3 January 2017 issue of … Continue reading

Posted in Ideas | Comments Off on Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Valproic acid and Deoxycholic acid, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 23/February/2017, 10.38 pm

Natural product-derived antiviral therapy for HIV virus: Shikonin, isolated from Zicao (also known as Purple gromwell, the dried root of Lithospermum erythrorhizon), increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 23/February/2017, 9.53 pm

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA shows that “Heme Oxygenase 2 Binds Myristate to Regulate … Continue reading

Posted in Ideas | Comments Off on Natural product-derived antiviral therapy for HIV virus: Shikonin, isolated from Zicao (also known as Purple gromwell, the dried root of Lithospermum erythrorhizon), increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 23/February/2017, 9.53 pm

Amino acid therapy for Metabolic diseases: Leucine increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene, 23/February/2017, 9.29 pm

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published in the June 8, 2011 Nature [One of the best … Continue reading

Posted in Ideas | Comments Off on Amino acid therapy for Metabolic diseases: Leucine increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene, 23/February/2017, 9.29 pm

Natural product-derived therapy for Diabetic Kidney disease: Naringenin, a flavanone found in grapefruit, oranges, and water mint among others, decreases VEGF-B expression, inhibits lipid accumulation in Podocytes, promotes insulin signalling in Podocytes, induces insulin sensitivity, ameliorates renal dysfunction and alleviates diabetic kidney disease via down regulation of its target gene, 23/February/2017, 7.03 am

Introduction: What they say A study from the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden shows that “Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.” This research … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for Diabetic Kidney disease: Naringenin, a flavanone found in grapefruit, oranges, and water mint among others, decreases VEGF-B expression, inhibits lipid accumulation in Podocytes, promotes insulin signalling in Podocytes, induces insulin sensitivity, ameliorates renal dysfunction and alleviates diabetic kidney disease via down regulation of its target gene, 23/February/2017, 7.03 am

Anti-telomerase cancer therapy: USP13 (Ubiquitin Specific Peptidase 13)/Isopeptidase T-3 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 22/February/2017, 11. 12 pm

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: USP13 (Ubiquitin Specific Peptidase 13)/Isopeptidase T-3 suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 22/February/2017, 11. 12 pm

Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of CCM1/KRIT1 and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 22/February/2017, 10.58 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of CCM1/KRIT1. Thereby, it may promote apoptosis, inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of CCM1/KRIT1 and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 22/February/2017, 10.58 pm

Vitamin therapy for Diabetic Kidney disease: Ascorbate/Vitamin-C, found abundantly in yellow pepper and amla among others, decreases VEGF-B expression, inhibits lipid accumulation in Podocytes, promotes insulin signalling in Podocytes, induces insulin sensitivity, ameliorates renal dysfunction and alleviates diabetic kidney disease via down regulation of its target gene, 22/February/2017, 2.02 pm

Introduction: What they say A study from the Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden shows that “Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease.” This research … Continue reading

Posted in Ideas | Comments Off on Vitamin therapy for Diabetic Kidney disease: Ascorbate/Vitamin-C, found abundantly in yellow pepper and amla among others, decreases VEGF-B expression, inhibits lipid accumulation in Podocytes, promotes insulin signalling in Podocytes, induces insulin sensitivity, ameliorates renal dysfunction and alleviates diabetic kidney disease via down regulation of its target gene, 22/February/2017, 2.02 pm

Natural product-derived antiviral therapy against HIV virus: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others,increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 22/February/2017, 10.31 am

Introduction: What they say A study from the Department of Biochemistry and Molecular Biophysics and Department of Microbiology and Immunology, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA shows that “Heme Oxygenase 2 Binds Myristate to Regulate … Continue reading

Posted in Ideas | Comments Off on Natural product-derived antiviral therapy against HIV virus: γ-Bisabolene, one of the components in Cardamom, Cubeb, lemon, and Oregano among others,increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 22/February/2017, 10.31 am

Molecular therapy for Bone disorders: Resistin, a pro-inflammatory cytokine, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via down-regulation of its target gene, 22/February/2017, 9.43 am

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2.” This study was published in the June 25, 2014 Nature  [I.F … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Bone disorders: Resistin, a pro-inflammatory cytokine, inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via down-regulation of its target gene, 22/February/2017, 9.43 am

Small molecule-based PD-1 pathway blockade for Human cancer therapy: Tumor suppressor Menin (MEN1), responsible for multiple endocrine neoplasia type 1 syndrome, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 22/February/2017, 9.33 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to … Continue reading

Posted in Ideas | Comments Off on Small molecule-based PD-1 pathway blockade for Human cancer therapy: Tumor suppressor Menin (MEN1), responsible for multiple endocrine neoplasia type 1 syndrome, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 22/February/2017, 9.33 pm

Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of BTG2 and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 21/February/2017, 11.16 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of BTG2. Thereby, it may promote apoptosis, inhibit migration, invasion and metastasis of cancer cells. Thus, … Continue reading

Posted in Ideas | Comments Off on Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of BTG2 and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 21/February/2017, 11.16 pm

MiRNA-based therapy for Metastatic human tumors: MiR-382 decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 21/February/2017, 11.08 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes … Continue reading

Posted in Ideas | Comments Off on MiRNA-based therapy for Metastatic human tumors: MiR-382 decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 21/February/2017, 11.08 pm

Vitamin-based therapy for glucose homeostasis and TIIDM: γ-Tocotrienol , a form of Vitamin-E found in Elaeis guineensis and among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 21/February/2017, 10.57 pm

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative … Continue reading

Posted in Ideas | Comments Off on Vitamin-based therapy for glucose homeostasis and TIIDM: γ-Tocotrienol , a form of Vitamin-E found in Elaeis guineensis and among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 21/February/2017, 10.57 pm

Anti-telomerase cancer therapy: Trefoil factor 1 (TFF1) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 21/February/2017, 5.33 pm

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.”  This study provides mechanistic insights into how … Continue reading

Posted in Ideas | Comments Off on Anti-telomerase cancer therapy: Trefoil factor 1 (TFF1) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 21/February/2017, 5.33 pm

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Calycosin, isolated from Radix astragali, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 21/February/2017, 12.15 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows that “Deubiquitination and Stabilization of PD-L1 by CSN5.” This study … Continue reading

Posted in Ideas | Comments Off on Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Calycosin, isolated from Radix astragali, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 21/February/2017, 12.15 pm

Interleukin therapy for Metastatic human tumors: IL-24 decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 20/February/2017, 10.16 pm

Introduction: What they say: A study from the State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China shows that “c-Src phosphorylation and activation of hexokinase promotes … Continue reading

Posted in Ideas | Comments Off on Interleukin therapy for Metastatic human tumors: IL-24 decreases the expression of c-Src protein, inhibits the expression of a number of enzymes in glycolytic cycle, and suppresses proliferation, migration, invasion, tumorigenesis and metastasis via up regulation of its target gene, 20/February/2017, 10.16 pm

Molecular therapy for Metabolic diseases: Combination of Amlodipine and Atorvastatin, a calcium channel blocker and an HMG-CoA reductase inhibitor, respectively, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 20/February/2017, 2.12 pm

What they say:   A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published in the 7 March  2013 issue of Nature  by Prof Dimmler, Boon, and others. What we say:  On the foundation of this interesting finding, Dr L … Continue reading

Posted in Ideas | Comments Off on Molecular therapy for Metabolic diseases: Combination of Amlodipine and Atorvastatin, a calcium channel blocker and an HMG-CoA reductase inhibitor, respectively, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up-regulation of PNUTS, 20/February/2017, 2.12 pm

Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: LRRC4/NGL2 (Leucine rich repeat containing 4/Netrin-G ligand-2) inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 20/February/2017, 1.51 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, Houston, TX 77030, USA shows that “Deubiquitination and Stabilization of PD-L1 by CSN5.” This study … Continue reading

Posted in Ideas | Comments Off on Small molecule-based PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: LRRC4/NGL2 (Leucine rich repeat containing 4/Netrin-G ligand-2) inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 20/February/2017, 1.51 pm

Natural product-derived therapy for glucose homeostasis and TIIDM: Quercetin, found in Elderberry and Onions among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 20/February/2017, 10.28 am

Introduction: What they say  A study from the Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel shows that “PAX6 maintains ß cell identity by repressing genes of alternative … Continue reading

Posted in Ideas | Comments Off on Natural product-derived therapy for glucose homeostasis and TIIDM: Quercetin, found in Elderberry and Onions among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of their target gene, 20/February/2017, 10.28 am