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February 5, 2017

Natural product-derived PD-1 pathway blockade for Human cancer therapy: BMP4 (Bone Morphogenetic Protein 4) inhibits the expression of co-inhibitory receptor PD-1 on Antigen- Specific T-cells, increases the production of cytokines by tumor-infiltrating lymphocytes (TIL), and draining lymph nodes and augments anti-tumor activity via down-regulation of its target gene, 5/February/2017, 11.33 pm

Introduction:What they say: A recent study from Division of Infectious Diseases, School of Medicine, Johns Hopkins University, Baltimore, MD 21218, United States shows that “TGF-β1-Mediated Smad3 […]
February 5, 2017

Molecular therapy for Bone disorders: Raf kinase Inhibitor Protein (RKIP) inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 5/February/2017, 11.20 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone […]
February 5, 2017

Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Bitter melon (Momordica charantia) extract (BME) decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 5/February/2017, 11.04 am

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]
February 5, 2017

Anticancer therapy: MiRNA-9600 decreases the expression of cell cycle regulator CDC25A, inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 5/February/2017, 7.50 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may inhibit the expression of Cell cycle regulator […]