06

February 6, 2017

Natural product-based Lifespan extension therapy: Kaemphferol, found in Aloe Vera, among others, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 6/February/2017, 10.48 pm

Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown […]
February 6, 2017

Molecular therapy for Bone disorders: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 6/February/2017, 10.34 pm

Introduction: What they say:  A study from the Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA has reported that “miR-34a blocks osteoporosis and bone […]
February 6, 2017

Anticancer therapy: MiRNA-9600 increases the expression of tumor suppressor PTPN14 (Pez), inhibits proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 6/February/2017, 10.19 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by decreasing the expression of its target genes, it may inhibit the expression of tumor suppressor PTPN14 […]
February 6, 2017

Natural product-derived antiviral therapy against chikungunya (CHIKV) and Zika (ZIKV) viruses: Casuarinin, a hydrolyzable tannin isolated from the bark of Terminalia arjuna Linn. (Combretaceae), decreases spermidine/spermine N1-acetyltransferase (SAT) expression, depletes spermidine and Spermine levels, and restricts Chikungunya and Zika viruses replication via up regulation of its target gene, 6/February/2017, 9.59 pm

Introduction: What they say A study from the Viral Populations and Pathogenesis Unit, Institut Pasteur, CNRS UMR 3569, 25–28 rue du Dr. Roux, 75724 Paris Cedex […]