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February 19, 2017

Small molecule-based PD-1 pathway blockade for Human cancer therapy: BMP2 (Bone Morphogenetic Protein-2) decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 19/February/2017, 11.11 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
February 19, 2017

Anti-telomerase cancer therapy: Genistein, isolated from Macckia Amurensis, Flemingia vestita, and soy among others, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 19/February/2017, 10.45 pm

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]
February 19, 2017

Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of Tissue inhibitor of metalloproteinases 3 (TIMP3) and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 19/February/2017, 2.26 pm

Research findings to Therapeutic opportunity:  The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of […]
February 19, 2017

Natural product-derived Anti-AXL therapeutics for enhancing the efficacy of chemotherapies: Combination of Rhamnetin and Hesperidin, found in Cloves and Citrus fruits, respectively, decreases the expression of the AXL receptor and its activating ligand, GAS6, increases the expression of a number of tumor suppressor genes, increases therapeutic index of anticancer drugs, suppresses tumorigenesis, migration, invasion, and metastasis via up regulation of its target gene, 19/January/2017, 11.33 am

Introduction: What they say: A study from the Department of Radiation Oncology, Stanford University School of Medicine shows that “Inhibition of the GAS6/AXL pathway augments the […]