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February 24, 2017

Natural product/vitamin-based Combination therapy for PTEN-deficient cancer: Combination of Schisandrin B, Cholecalciferol and ATRA decreases the expression of CHD1, increases the expression of a number of tumor suppressor genes, inhibits pro-survival TNF-NF-kB gene network, and suppresses tumorigenesis of PTEN-deficient cancer, 24/February/2017, 11.43 pm

Introduction: What they say: A study from the Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA shows that […]
February 24, 2017

Natural product-derived PD-L1 pathway blockade enhances the efficacy of Cancer immunotherapy: Bergapten, isolated from Bergamot, inhibits the expression of PD-L1, inhibits inflammatory signalling and the number of tumor-infiltrating lymphocytes and macrophages, increases Cytotoxic activity of T-cells, decreases tumor burden and increases survival via up-regulation of its target gene, 24/February/2017, 11.27 pm

Introduction:What they say: A recent study from Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Unit 108, 1515 Holcombe Boulevard, […]
February 24, 2017

Combination therapy for augmenting the anti-cancer drug 5-FU (5-Flurouracil) sensitivity in Human cancers: 15-deoxy-delta(12,14)-prostaglandin J2 (PGJ2) decreases the expression of the rate-limiting enzyme of the ‘uracil catabolic pathway’ Dihydropyrimidine dehydrogenase (DPYD), increases 5-FU accumulation in cancer cells, augments chemosensitivity, and anti-tumor effect via upregulation of its target gene, 24/January/2017, 11.01 pm

From Research findings to Therapeutic opportunity:  The study presented here suggests that 15-deoxy-delta(12,14)-prostaglandin J2 (PGJ2), by increasing the expression of its target genes, it may: (i) decrease the […]
February 24, 2017

Anticancer therapy targeting the cancer stem cells: MiRNA-9600 inhibits the expression of stem cell gene/reprogramming protein Nanog, suppresses proliferation, and promotes apoptosis of cancer cells via down regulation of its target gene, 24/January/2016, 10.53 pm

Research findings to Therapeutic opportunity:   The study presented here suggests that MiRNA-9600, by increasing the expression of its target genes, it may decrease the expression of protein that is […]