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February 27, 2017

Small molecule-based PD-1 pathway blockade for Human cancer therapy: Metformin, the widely used drug in the treatment of TIIDM, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 27/February/2017, 9.27 pm

Introduction:What they say:  A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK […]
February 27, 2017

Natural product-based therapy for Metabolic diseases: Fla-CN, a flavonoid derivative of tiliroside, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 27/February/2017, 6.32 pm

Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” […]
February 27, 2017

Vitamin-based therapy for Metastatic cancers: Ascorbate, found abundantly in Kakadu plum/murunga, and camucamu among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/February/2017, 8.36 am

From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more […]
February 27, 2017

Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]