Introduction: What they say:
The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function.
What we say:
In connection with this finding, Dr Boominathan, Founder Director-cum-chief scientist of GBMD, reports, for the first time, that: Anti-telomerase cancer therapy: Oridonin, isolated from Rabdosia rubescens, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene
Significance of the study:
Given that: (1) over 90% human tumors overexpress immortality gene telomerase; and (2) cancer causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a way to inhibit telomerase activity in human tumors; (ii) a way to increase the efficacy of anticancer therapy; (iii) a cheaper alternative to the existing expensive drugs; (iv) a side-effect-free natural product-based drug; (v) a way to effectively treat cancers that are resistant to anticancer drugs; (vi) a way to prevent tumor recurrence; and (vii) a way to effectively treat and eradicate metastatic progression of cancer.
From Research Findings to Therapeutic opportunity:
This study suggests that Oridonin, by regulating the expression of its downstream target genes (Fig. 1), it may suppress the expression of Tripeptidyl Peptidase 1 (TPP1) and Telomerase (Fig 1). Remarkably, over 90% of the human tumors overexpress the cellular immortality gene telomerase, suggesting that inhibition of its activity may increase the efficacy of anticancer therapy.
Taken together, pharmacological formulations encompassing “Oridonin or its analogs or Oridonin in combination with other anticancer drugs” may be considered to treat human cancers that specifically overexpress the cellular immortality gene telomerase.
Details of the Research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How Oridonin suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and telomerase?
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Citation: Boominathan, L., Anti-telomerase cancer therapy: Oridonin, isolated from Rabdosia rubescens, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 13/February/2017, 7.05 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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