Life-extension therapy: Alantolactone, present in Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 2/February/2017, 11.57 pm

Natural product-derived therapy for glucose homeostasis and TIIDM:Opuntia ficus-indica extract (OFIE) increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 2/February/2017, 11.35 pm
February 2, 2017
Anti-telomerase cancer therapy: Didimyn, found in Origanum vulgare and Citrus fruits, suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 3/February/2017, 11.54 am
February 3, 2017
Show all

What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Life-extension therapy: Alantolactone, present in Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity: 

Alanolactone, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

Alanolactone inhibits p70S6 kinase and extends mamalian lifespan

Figure 1. Mechanistic insight into how Alanolactone may extend lifespan. Alanolactone, found in Inula Japonica, among others, inhibits p70 S6 kInase expression and promotes longevity

Inula helenium, க்கான பட முடிவு

Figure 2. Alantolactone, found in Inula helenium, extends mammalian life span via down regulation of p70 S6 Kinase

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing “Alanolactone  or its analog either alone or in combination with any of the known longevity-promoting compound(s) may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How  Alanolactone  decreases the expression of p70 S6 Kinase and promote mammalian life span

# Research cooperation

Amount: $50#

For purchase and payment information, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L.,   Life-extension therapy: Alantolactone, present in Inula helenium, L. Inula japonica, Aucklandia lappa, Inula racemosa, and Radix inulae, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 2/February/2017, 11.57 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.