Life-extension therapy: Hesperitin, found in Citrus fruits, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 7/February/2017, 11.01 pm

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What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Life-extension therapy: Hesperitin, found in Citrus fruits, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span



Research findings to Therapeutic opportunity: 

Hesperetin inhibit p70 S kianse

Figure 1. Mechanistic insight into how Hesperitin may extend lifespan. Hesperitin, found in Citrus fruits, among others, inhibits p70 S6 kInase expression and promotes longevity

Hesperitin, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

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orange peel isolated on white background

Figure 2. Citrus peel: Citrus peel extends mammalian life span via down regulation of p70 S6 Kinase

Citrus fruits

Figure 3. Citrus fruits

Thus, pharmacological formulations encompassing Hesperitin  or its analogs either alone or in combination with any of the known longevity-promoting compound(s) may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed mechanistic Information: How  Hesperitin  decreases the expression of p70 S6 Kinase and promote mammalian life span

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References:

CitationBoominathan, L., Life-extension therapy: Hesperitin, found in Citrus fruits, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 7/February/2017, 11.01 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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