Life-extension therapy: Orphan nuclear receptor Nur77/NGFI-B inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/February/2017, 6.47 pm

Natural product-based therapy for Metastatic tumors: Formononetin, an isoflavone found in the roots of astragalus membranaceus, Trifolium pratense, Glycyrrhiza glabra, and Pueraria lobata, increases the expression of tumor suppressor gene PDCD4 and promotes apoptosis of tumor cells via down regulation of its target gene, 5/February/2017, 6.23 pm
February 5, 2017
Natural product-based Lifespan extension therapy: Casticin, found in VITEX agnus-castus, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 5/February/2017, 7.00 pm
February 5, 2017
Show all

What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ) by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Life-extension therapy: Orphan nuclear receptor Nur77/NGFI-B inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity: 

Nur77/NGFI-B, by  decreasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

NUR77 inhibits p70 S6 Kinase expression and extends mammalian life span

Figure 1. Mechanistic insight into how NUR77/NGFI-B may extend lifespan. NUR77/NGFI-B inhibits p70 S6 kInase expression and promotes longevity

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing Nur77/NGFI-B activators may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How  Nur77/NGFI-B  decreases the expression of p70 S6 Kinase and promote mammalian life span

# Research cooperation

Amount: $50#

For purchase and payment information, you may reach us at info@genomediscovery.org


References:

CitationBoominathan, L.,    Life-extension therapy: Orphan nuclear receptor Nur77/NGFI-B inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 5/February/2017, 6.47 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.