Natural product-based Lifespan extension therapy: Arecoline/Areca nut extract prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 8/February/2017, 9.25 pm

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Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 


From research findings to therapeutic opportunity

This study suggests, for the first time, that Arecoline, by increasing the expression of its target gene,  it may decrease the expression of AT1R.

Areca nut palm

Figure1. Areca nut tree. Areca nut extract or Arecoline functions as a longevity-promoting agent via down regulation of A1TR

Arecoline க்கான பட முடிவு

Figure 2. Arecoline inhibits A1TR expression and extends life-span

And, thereby, it may (1) decrease blood pressure; (2) decrease blood sugar levels; (3) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Arecoline or its analogues or Arecoline in combination with other natural products” may be used to extend the lifespan of an individual (Figure 1).


Details of the research findings

Idea Proposed/Formulated byDr L Boominathan Ph.D.  

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How  does Arecoline suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $100

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


References

CitationBoominathan, L., Natural product-based Lifespan extension therapy: Arecoline/Areca nut extract prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 8/February/2017, 9.25 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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