Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Casticin, by increasing the expression of its target gene, it may decrease the expression of AT1R.
And, thereby, it may (1) decrease blood pressure; (2) decrease blood sugar levels; (3) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Casticin or its analogues or Casticin in combination with other natural products” may be used to extend the lifespan of an individual (Figure 1).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Casticin suppress the expression of angiotensin II type I receptor (AT1R)?
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# Research cooperation
Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Casticin, found in VITEX agnus-castus, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 5/February/2017, 7.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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