Natural product-based Lifespan extension therapy: Casticin, found in VITEX agnus-castus, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 5/February/2017, 7.00 pm
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February 5, 2017Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Casticin, by increasing the expression of its target gene, it may decrease the expression of AT1R.
Figure 1. VITEX agnus-castus. Casticin, found in VITEX agnus-castus, inhibits AT1R expression and prolongs mammalian lifespan via up regulation of its target gene
Figure 2. Casticin inhibits A1TR expression and extends life-span
And, thereby, it may (1) decrease blood pressure; (2) decrease blood sugar levels; (3) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Casticin or its analogues or Casticin in combination with other natural products” may be used to extend the lifespan of an individual (Figure 1).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Casticin suppress the expression of angiotensin II type I receptor (AT1R)?
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References:
Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Casticin, found in VITEX agnus-castus, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 5/February/2017, 7.00 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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