Natural product-based Lifespan extension therapy: Kaemphferol, found in Aloe Vera, among others, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 6/February/2017, 10.48 pm

Molecular therapy for Bone disorders: LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2) inhibits the expression of Tgif2 and suppresses osteoporosis and bone metastasis via up-regulation of its target gene, 6/February/2017, 10.34 pm
February 6, 2017
Natural product-derived therapy for glucose homeostasis and TIIDM: Ellagic acid, found in walnuts, pecans, cranberries, raspberries, and strawberries, among others, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 7/February/2017, 7.04 am
February 7, 2017
Show all

Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 


From research findings to therapeutic opportunity

This study suggests, for the first time, that Kaemphferol, by increasing the expression of its target gene,  it may decrease the expression of AT1R.

Aloe vera க்கான பட முடிவு

Fig 1. Aloe Vera. Kaempferol, found in Aloe vera, among others,  functions as a longevity-promoting agent via down regulation of A1TR

க்கான பட முடிவு

Figure 1. Kaempferol inhibits A1TR expression and extends life-span

And, thereby, it may (1) decrease blood pressure; (2) decrease blood sugar levels; (3) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Kaemphferol or its analogues or Kaemphferol in combination with other natural products” may be used to extend the lifespan of an individual (Figure 1).


Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.  

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How  does Kaemphferol suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $100

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


References

CitationBoominathan, L., Natural product-based Lifespan extension therapy: Kaemphferol, found in Aloe vera, among others, prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 6/February/2017, 10.48 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.