Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Piper betle leaf (PBLs), by increasing the expression of its target gene, it may decrease the expression of AT1R.
And, thereby, it may (1) decrease blood pressure; (2) decrease blood sugar levels; (3) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Piper betle leaf (PBLs) or an active compound isolated from it or Piper betle leaf (PBLs) in combination with other natural products” may be used to extend the lifespan of an individual (Figure 1).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Piper betle leaf (PBLs) extract suppress the expression of angiotensin II type I receptor (AT1R)?
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Citation: Boominathan, L., Natural product-based Lifespan extension therapy: Piper betle leaf (PBLs) prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 3/February/2017, 11.35 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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