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Research findings to Therapeutic opportunity: 

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The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of CCM1/KRIT1. Thereby, it may promote apoptosis, inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “(6)-gingerol (6G) or its analogues” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How (6)-gingerol (6G) increases the expression of metastasis suppressor CCM1/KRIT1

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References: 

CitationBoominathan, L., Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of CCM1/KRIT1 and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 22/February/2017, 10.58 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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