Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of Sprouty-1/2 (SPRY-1/2) and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 24/February/2017, 10.31 pm

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Research findings to Therapeutic opportunity: 

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The study presented here suggests that (6)-gingerol (6G), by increasing the expression of its target genes, it may increase the expression of Sprouty-1/2 (SPRY-1/2). Thereby, it may promote apoptosis, inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “(6)-gingerol (6G) or its analogues” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Undisclosed information: How (6)-gingerol (6G) increases the expression of metastasis suppressor Sprouty-1/2 (SPRY-1/2)

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References: 

CitationBoominathan, L., Natural product-based therapy for Metastatic cancers: (6)-gingerol (6G), one of the main components of Ginger, increases the expression of Sprouty-1/2 (SPRY-1/2) and promotes apoptosis, inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 24/February/2017, 10.31 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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