Natural product-derived PD-1 pathway blockade for Human cancer therapy: Apigenin (APG), a flavone commonly found in fruits and vegetables, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 17/February/2017, 11.59. pm

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Introduction:What they say

A recent study from Cell Signalling Section, Division of Immunology, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge CB2 1QP, UK shows that “Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.” This study was published in the 16 February 2016 issue of Immunity (one of the best journals in Immunology with an impact factor of 20+) by Prof Rudd CE, Taylor A and others.


What we say

price-50

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived PD-1 pathway blockade for Human cancer therapy: Apigenin (APG), a flavone commonly found in fruits and vegetables, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene


What is known?

It has recently been shown that blocking PD-1 with antibodies one could make tumors shrink. This work, relating to Cancer immunotherapy, has been chosen as Science’s breakthrough of the year.


Research Findings

This study suggests a natural product-derived therapy for human cancers. A therapeutic mix encompassing Apigenin (APG)by inhibiting the activity of Glycogen synthase kinase 3-β, it may: (a) increase transcription factor T-bet expression; (b) inhibit co-inhibitory receptor PD-1 expression;  (c) increase CD8(+) cytotoxic T lymphocyte function; (d) augment anti-tumor activity; & (e) inhibit metastatic cancer progression (figs. 1-3)

Apigenin க்கான பட முடிவு

Fig 1 Apigenin (APG) serves as an anti-tumor immunity booster. Apigenin increases T-bet expression, inhibits PD-1 expression, and augments anti-tumor immunity

parsley க்கான பட முடிவு

Figure 2. Parsley. Apigenin (APG), found in Parsley, augments anti-tumor immunity via down regulation of PD-1

celery க்கான பட முடிவு

Figure 3. Celery. Apigenin (APG), found in Celery, functions as an antitumor immunity booster.


Therapeutic opportunity

Thus, pharmacological formulations encompassing Apigenin (APG) or its analogues may be used to inhibit the progression of tumors.


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $50

Undisclosed information: How does Apigenin (APG) suppress the expression of PD-1 to promote anti-tumor immunity?

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References:

Citation: Boominathan, L.,  Natural product-derived PD-1 pathway blockade for Human cancer therapy: Apigenin (APG), a flavone commonly found in fruits and vegetables, decreases the activity of Glycogen synthase kinase-3β, increases transcription factor T-bet expression, decreases the abundance of co-inhibitory receptor PD-1 on the cell surface of Cytotoxic-T-cells, increases cytotoxic T lymphocyte function and augments anti-tumor activity, via up-regulation of its target gene, 17/February/2017, 11.59 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com/

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