Natural product therapy for pulmonary arterial hypertension: EGCG (Epigallocatechin-3-gallate), one of the main components of Green tea, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 8/February/2017, 8.56 am

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What they say: 

A study from the University of California, La Jolla, California, USA shows that Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension: EGCG (Epigallocatechin-3-gallate), one of the main components of Green tea,  inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3


Significance of the study:  

EGCGby increasing the expression of its target gene, it may decrease the expression of Notch3. 

EGCG க்கான பட முடிவு

Figure 1. The chemical structure of EGCG

green tea க்கான பட முடிவு

Figure 2. Green tea. EGCG, one of the main components of Green tea, inhibits the development of pulmonary hypertension via up regulation of its target gene

Thus, pharmacological formulations encompassing “EGCG or its analog or EGCG in combination with other drugs” may be used to treat pulmonary arterial hypertension.


Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Undisclosed mechanistic information: How EGCG decreases the expression of Notch3 

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References: 

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L.,  Natural product therapy for pulmonary arterial hypertension:  EGCG (Epigallocatechin-3-gallate), one of the main components of Green tea,  inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 8/February/2017,  8.55 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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