Natural product therapy for pulmonary arterial hypertension: Shikonin, found in Zicao (also known as purple gromwell), inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 13/February/2017, 3.42 pm

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What they say: 

A study from the University of California, La Jolla, California, USA shows that Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published in the 15 November  2009 issue of the journalNature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054] by Prof. Thistlethwaite PA, Li X and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product therapy for pulmonary arterial hypertension:  Shikonin, found in Zicao (also known as purple gromwell)inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3


Significance of the study:  

Shikoninby increasing the expression of its target gene, it may decrease the expression of Notch3 (Figs.1-2). 

purple-gromwell

Figure 1. Zicao. Shikonin, found in Zicao (also known as purple gromwell), inhibits the development of pulmonary hypertension via up regulation of its target gene

Figure 2. The chemical structure of Shikonin

Thus, pharmacological formulations encompassing Shikonin or its analog or Shikonin in combination with other drugs” may be used to treat pulmonary arterial hypertension.


Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Undisclosed mechanistic information: How Shikonin decreases the expression of Notch3 

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References: 

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CitationBoominathan, L.,  Natural product therapy for pulmonary arterial hypertension:  Shikonin, found in Zicao (also known as purple gromwell)inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 13/February/2017,  3.42 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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