Natural product-based therapy for Metabolic diseases: Fla-CN, a flavonoid derivative of tiliroside, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 27/February/2017, 6.32 pm
Introduction: What they say A study from the Institute for Molecular Systems Biology, ETH Zurich, Zurich, Switzerland shows that “MicroRNAs 103 and 107 regulate insulin sensitivity.” This study was published in the June 8, 2011 Nature [One of the best journals in Science with an I.F of >43] by Prof. Stoffel M, Trajkovski M and […]
Vitamin-based therapy for Metastatic cancers: Ascorbate, found abundantly in Kakadu plum/murunga, and camucamu among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/February/2017, 8.36 am
From Significance of the study to Public health relevance: Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) cancer treatment causes the highest economic loss compared to all the […]
Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am
Introduction: What they say: The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity.” This study provides mechanistic insights into how TPP1 regulates telomerase function. What we say: In connection with this finding, Dr Boominathan, Founder […]
Natural product-derived therapy for Human Leukemias: Gentian Violet, isolated from Gentianopsis Crinita, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 27/February/2017, 5.38 am
Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms by which MiR-125b represses IRF4 to induce myeloid/B-cell leukemias.” What we say: On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Natural product-derived therapy for Human Leukemias: Gentian […]
Natural product-derived therapy for glucose homeostasis and TIIDM: Oliganol, isolated from fruit Lynchee, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 26/February/2017, 11.47 pm
Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in the September 14, 2014 issue of the Journal “Journal of Experimental Medicine (JEM)” that: “The microRNA-212/132 cluster regulates B cell development by targeting Sox4.” Subsequently, Prof. Rorsman’s research team, […]
Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 26/February/2017, 11.14 am
Research findings to Therapeutic opportunity: A number of studies suggest that Hyperoside functions as an anticancer agent. However, the mechanism of action is far from clear. This study suggests that Hyperoside, by decreasing the expression of its target genes, it may increase the expression of metastasis suppressor TPM1 (figs. 1-4). Thereby, it may inhibit migration, invasion […]
