February

February 27, 2017

Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am

Introduction: What they say:   The 1989 Nobel prize winner in Chemistry, Prof. Thomas R. Cech from the BioFrontiers Institute, USA has published a research paper in the 13 December 2012 issue of the Nature journal (492(7428):285-9; and I.F: >42) stating that “The TEL […]
February 27, 2017

Natural product-derived therapy for Human Leukemias: Gentian Violet, isolated from Gentianopsis Crinita, suppresses B-Cell and myeloid leukemias via up regulation of the tumor suppressor IRF4, 27/February/2017, 5.38 am

Introduction: What they say Noble laureate in Physiology/Medicine (1975) Prof. David Baltimore, from California Institute of Technology, California, USA, had reported in the July 8, 2014 issue of the Journal “Blood” that: “Dual mechanisms […]
February 26, 2017

Natural product-derived therapy for glucose homeostasis and TIIDM: Oliganol, isolated from fruit Lynchee, inhibits Amysin expression, increases insulin secretion, and decreases the risk of hyperglycemia via down regulation of its target gene Sox4, 26/February/2017, 11.47 pm

Introduction: What they say Nobel laureate in Physiology/Medicine (1975) Prof. David Baltimore and his research team, from California Institute of Technology, California, USA, had reported in […]
February 26, 2017

Natural product-based therapy for Metastatic cancers: Hyperoside, isolated from Drosera rotundifolia, and Common self-heal, among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 26/February/2017, 11.14 am

Research findings to Therapeutic opportunity:  A number of studies suggest that Hyperoside functions as an anticancer agent. However, the mechanism of action is far from clear. […]