Vitamin-based therapy for Metastatic cancers: Ascorbate, found abundantly in Kakadu plum/murunga, and camucamu among others, increases the expression of TPM1 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/February/2017, 8.36 am

Anti-telomerase cancer therapy: OTUD3 (OTU Deubiquitinase 3) suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 27/February/2017, 5. 53 am
February 27, 2017
Natural product-based therapy for Metabolic diseases: Fla-CN, a flavonoid derivative of tiliroside, increases the expression of Caveolin-1, stabilizes insulin receptor, promotes insulin sensitivity, incrases vasorelaxation, and decreases the risk of hyperglycemia and TIIDM via up regulation of its target gene.., 27/February/2017, 6.32 pm
February 27, 2017
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From Significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a way to prevent an individual from being susceptible to cancer by strengthening his/her own immune system (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


Research findings to Therapeutic opportunity: 

A number of studies suggest that Ascorbate functions as an anticancer agent. However, the mechanism of action is far from clear.

This study suggests that Ascorbate, by increasing the expression of its target genes, it may decrease the expression of metastasis suppressor PMP22 (figs. 1-3).

Ascorbate inhibits PMP22

Fig1. Mechanistic insights into how Ascorbate functions as an anti-metastasis agent

Kakadu plum க்கான பட முடிவு

Figure 2. Kakadu plum. Kakadu fruit contains  2300-5300 mg/100g of Ascorbic acid compared to 50mg/100g of Oranges. It functions as an antimetastatic agent by decreasing the expression of PMP22

Price 10

camu camu க்கான பட முடிவு

Figure 2. Camu Camu (Myrciaria dubia). Camu Camu fruit contains 2800 mg/100g of Ascorbic acid compared to 50mg/100g of Oranges

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Thereby, it may inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing Ascorbate or its analogues either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $10

Undisclosed information: How Ascorbate decreases the expression of metastasis suppressor PMP22

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

CitationBoominathan, L., Vitamin-based therapy for Metastatic cancers: Ascorbate, found abundantly in Kakadu plum/murunga, and camucamu among others, decreases the expression of PPM22 and inhibits migration, invasion and metastasis of cancer cells via down regulation of its target gene, 27/February/2017, 8.36 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite drop us a line at info@genomediscovery.org

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