Significance of the study:
It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan.
From research findings to therapeutic opportunity:
This study suggests, for the first time, that Leucine, by increasing the expression of its target genes, it may decrease the expression of AT1R.
And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Leucine or its analogues or Leucine in combination with other anti-ageing/longevity promoting compounds” may be used to extend the lifespan of an individual (Figures 1-2).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How does Leucine suppress the expression of angiotensin II type I receptor (AT1R)?
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Citation: Boominathan, L., Amino acid-based Lifespan extension therapy: L-Leucine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 22/March/2017, 9.14 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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