MiRNA-based Life-span extension therapy: MiR-497 may increase lifespan by suppressing mTOR pathway, 21/March/2016, 11.59 pm

Natural product-derived therapy for pulmonary fibrosis: Fla-CN, a flavonoid derivative of tiliroside, decreases miR-34 expression, increases Sirtuin-1 expression, suppresses tumor suppressor p53 acetylation, prevents apoptosis in Alveolar epithelial cell (AEC), and improves pulmonary fibrosis via down regulation of its target gene, 21/March/2017, 11.54 pm
March 21, 2017
Anti-telomerase cancer therapy: Forsythiae Fructus extract suppresses the expression of Tripeptidyl Peptidase 1 (TPP1) and the cellular immortality gene telomerase and inhibits cancer progression via down-regulation of it target gene, 22/March/2017, 7.23 am
March 22, 2017
Show all

What is known

It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters.” 


From research findings to therapeutic opportunity

This study suggests that MiR-497, by suppressing the expression of mTOR, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. 


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:Price 2

[easy_payment currency=”USD”]

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $2#

For purchase and payment details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., MiRNA-based Life-span extension therapy: MiR-497 may increase lifespan by suppressing mTOR pathway, 21/March/2016, 11.59 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.