MiRNA-based Life-span extension therapy: MiR-497 may increase lifespan by suppressing mTOR pathway, 21/March/2016, 11.59 pm

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What is known

It has been shown earlier that decreasing the expression/activity of mTOR increases overall mammalian lifespan, suggesting that mTOR inhibitors may function as “longevity promoters.” 

From research findings to therapeutic opportunity

This study suggests that MiR-497, by suppressing the expression of mTOR, it may: (i) increase autophagic flux; (ii) decrease reactive oxygen species; and (iii) increase  the lifespan of an individual. 

Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:Price 2

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Dr L Boominathan Ph.D.

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CitationBoominathan, L., MiRNA-based Life-span extension therapy: MiR-497 may increase lifespan by suppressing mTOR pathway, 21/March/2016, 11.59 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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