Molecular therapy for Metastatic cancers: α-Solanine, isolated from Flowers and Fruits of bittersweet nightshade, decreases the expression of PPM22 and inhibits migration, invasion and metastasis of cancer cells via up regulation of its target gene, 4/March/2017, 7.21 am

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From Significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) a way to prevent an individual from being susceptible to cancer by strengthening his/her own immune system (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


Research findings to Therapeutic opportunity: 

A number of studies suggest that α-Solanine functions as an anticancer agent. However, the mechanism of action is far from clear.

This study suggests that  α-Solanine, by increasing the expression of its target genes, it may decrease the expression of metastasis promoter PMP22 (fig. 1).

aSolanine inhibits PMP22 expression

Fig1. Mechanistic insights into how α-Solanine functions as an anti-metastasis agent

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Thereby, it may inhibit migration, invasion and metastasis of cancer cells. Thus, pharmacological formulations encompassing “α-Solanine or its analogues either alone or in combination with other anticancer drugs” may be used to inhibit the progression of invasive tumors.


Details of the research findings

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $2

Undisclosed information: How α-Solanine decreases the expression of metastasis suppressor PMP22

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

CitationBoominathan, L., Molecular therapy for Metastatic cancers: α-Solanine, isolated from Flowers and Fruits of bittersweet nightshade, decreases the expression of PPM22 and inhibits migration, invasion and metastasis of cancer cells via up regulation of its target gene, 4/March/2017, 7.21 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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